A Multicentre Randomized Controlled Trial of Recombinant Interferon-Alpha-2a in the Treatment of Patients with Chronic Hepatitis C
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چکیده
منابع مشابه
A randomized controlled trial of recombinant interferon-alpha in chronic hepatitis C in hemophiliacs.
Chronic liver disease associated with hepatitis C virus (HCV) is an important cause of morbidity and mortality in hemophilia. We have used recombinant interferon alpha-2b (IFN alpha-2b) in a randomized controlled liver biopsy trial to treat hemophiliacs with chronic hepatitis. Eighteen patients entered the study, 16 of whom were subsequently shown to have antibodies to the HCV. All underwent li...
متن کاملInterferon alpha 2a in patients of chronic hepatitis C.
Hoofnagle et al. were the first to describe that interferon alpha, when given to patients with non-A, non-B hepatitis, was able to normalize liver enzyme levels in a substantial number of patients. They also noted that relapses might occur if treatment was discontinued1. This observation was confirmed by other smaller controlled and uncontrolled studies. Subsequently the genome of HCV was clone...
متن کاملTreatment of chronic hepatitis C with recombinant interferon alpha 2b.
The authors studied 70 patients affected by chronic hepatitis C where diagnosis had been made by clinical and histological tests. Intramuscular recombinant alpha 2b interferon (3 x 10(6)) was administered to 35 patients every second evening for 6 months, whereas the other 35 received aspecific treatment. Our results revealed normalization of transaminase in 57% of the patients, with distinct im...
متن کاملSafety and Efficacy of Pegylated Interferon Alfa-2a for the Treatment of Hepatitis C in Patients with Major Thalassemia
Background: Hepatitis C virus (HCV) infection is the most common transfusion transmitted disease in poly-transfused patients worldwide. In this study we aimed to evaluate the effects of pegylated interferon alfa-2a (PEG-IFN A-2a) in reducing serum ALT and eradicating serum hepatitis C virus (HCV) RNA in HCV infected polytransfused thalassemic patients. Materials and Methods: A cohort of 51 HCV-...
متن کاملA Randomized Controlled Trial of Recombinant Interferon-a in Chronic Hepatitis C in Hemophiliacs
Chronic liver disease associated with hepatitis C virus (HCV) is an important cause of morbidity and mortality in hemophilia. We have used recombinant interferon a-2b (IFNa-2b) in a randomized controlled liver biopsy trial to treat hemophiliacs with chronic hepatitis. Eighteen patients entered the study, 16 of whom were subsequently shown to have antibodies to the HCV. All underwent liver biops...
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ژورنال
عنوان ژورنال: Canadian Journal of Gastroenterology
سال: 1997
ISSN: 0835-7900
DOI: 10.1155/1997/454395